ID:DDX21_HUMAN DESCRIPTION: RecName: Full=Nucleolar RNA helicase 2; EC=3.6.4.13; AltName: Full=DEAD box protein 21; AltName: Full=Gu-alpha; AltName: Full=Nucleolar RNA helicase Gu; AltName: Full=Nucleolar RNA helicase II; AltName: Full=RH II/Gu; FUNCTION: Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription. Involved in rRNA processing. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. SUBCELLULAR LOCATION: Nucleus, nucleolus. DOMAIN: The two enzymatic activities reside in two separate domains, the helicase in the N-terminus and the foldase in the C- terminus. DOMAIN: The 3 X 5 AA repeats seem to be critical for the RNA folding activity (By similarity). MISCELLANEOUS: Autoantibodies against DDX21 are found in patients with watermelon stomach disease, which is characterized by prominent stripes of ectatic vascular tissue in the stomach similar to stripes on a watermelon. SIMILARITY: Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain. SEQUENCE CAUTION: Sequence=AAB02546.1; Type=Erroneous initiation;
ModBase Predicted Comparative 3D Structure on Q9NR30
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