Human Gene COMT (ENST00000449653.5) Description and Page Index

Description: Homo sapiens catechol-O-methyltransferase (COMT), transcript variant 4, mRNA. (from RefSeq NM_007310)
Gencode Transcript: ENST00000449653.5
Gencode Gene: ENSG00000093010.15
Transcript (Including UTRs)
Position: hg38 chr22:19,962,570-19,968,998 Size: 6,429 Total Exon Count: 4 Strand: +
Coding Region
Position: hg38 chr22:19,962,677-19,968,736 Size: 6,060 Coding Exon Count: 4

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: COMT_HUMAN DESCRIPTION: RecName: Full=Catechol O-methyltransferase; EC=2.1.1.6; FUNCTION: Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. CATALYTIC ACTIVITY: S-adenosyl-L-methionine + a catechol = S- adenosyl-L-homocysteine + a guaiacol. COFACTOR: Binds 1 magnesium ion per subunit. INTERACTION: Q9H0D6:XRN2; NbExp=1; IntAct=EBI-372265, EBI-372110; SUBCELLULAR LOCATION: Isoform Soluble: Cytoplasm. SUBCELLULAR LOCATION: Isoform Membrane-bound: Cell membrane; Single-pass type II membrane protein; Extracellular side. TISSUE SPECIFICITY: Brain, liver, placenta, lymphocytes and erythrocytes. PTM: The N-terminus is blocked. MASS SPECTROMETRY: Mass=24352; Mass_error=2; Method=Electrospray; Range=52-271; Source=PubMed:8020475; POLYMORPHISM: Two alleles, COMT1 or COMTH with Val-158 and COMT2 or COMTL with Met-158 are responsible for a three to four- fold difference in enzymatic activity. POLYMORPHISM: Low enzyme activity alleles are associated with genetic susceptibility to alcoholism [MIM:103780]. SIMILARITY: Belongs to the mammalian catechol-O-methyltransferase family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/comt/"; WEB RESOURCE: Name=Wikipedia; Note=Catechol-O-methyl transferase entry; URL="http://en.wikipedia.org/wiki/Catechol-O-methyl_transferase";

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR025782 - Catechol_O-MeTrfase
IPR017128 - Catechol_O-MeTrfase_euk
IPR002935 - O-MeTrfase_3

Pfam Domains:
PF01596 - O-methyltransferase

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3A7E - X-ray

3BWM - X-ray

3BWY - X-ray

ModBase Predicted Comparative 3D Structure on P21964


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