Human Gene BAG5 (ENST00000337322.4) Description and Page Index

Description: Homo sapiens BAG cochaperone 5 (BAG5), transcript variant 1, mRNA. (from RefSeq NM_001015049)
Gencode Transcript: ENST00000337322.4
Gencode Gene: ENSG00000166170.10
Transcript (Including UTRs)
Position: hg38 chr14:103,559,619-103,562,298 Size: 2,680 Total Exon Count: 2 Strand: -
Coding Region
Position: hg38 chr14:103,559,821-103,562,007 Size: 2,187 Coding Exon Count: 2

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: BAG5_HUMAN DESCRIPTION: RecName: Full=BAG family molecular chaperone regulator 5; Short=BAG-5; AltName: Full=Bcl-2-associated athanogene 5; FUNCTION: Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding. SUBUNIT: Binds to the ATPase domain of HSP/HSC70 chaperones. Binds PARK2 (By similarity). DOMAIN: The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain. SIMILARITY: Contains 5 BAG domains. SEQUENCE CAUTION: Sequence=BAA74896.1; Type=Erroneous initiation;

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR003103 - BAG_domain

Pfam Domains:
PF02179 - BAG domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2D9D - NMR

3A8Y - X-ray

ModBase Predicted Comparative 3D Structure on Q9UL15


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