Human Gene SNX9 (ENST00000392185.8) Description and Page Index
  Description: Homo sapiens sorting nexin 9 (SNX9), mRNA. (from RefSeq NM_016224)
Gencode Transcript: ENST00000392185.8
Gencode Gene: ENSG00000130340.16
Transcript (Including UTRs)
   Position: hg38 chr6:157,823,246-157,945,077 Size: 121,832 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg38 chr6:157,823,435-157,942,838 Size: 119,404 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther NamesMethods
Data last updated at UCSC: 2021-06-20 19:51:40

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:157,823,246-157,945,077)mRNA (may differ from genome)Protein (595 aa)
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-  Comments and Description Text from UniProtKB
  ID: SNX9_HUMAN
DESCRIPTION: RecName: Full=Sorting nexin-9; AltName: Full=SH3 and PX domain-containing protein 1; Short=Protein SDP1; AltName: Full=SH3 and PX domain-containing protein 3A;
FUNCTION: May be involved in several stages of intracellular trafficking. Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis. Plays a role in macropinocytosis. Promotes internalization of TNFR. Promotes degradation of EGFR after EGF signaling. Stimulates the GTPase activity of DNM1. Promotes DNM1 oligomerization. Promotes activation of the Arp2/3 complex by WASL, and thereby plays a role in the reorganization of the F- actin cytoskeleton. Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation. Has lower affinity for membranes enriched in phosphatidylinositol 3-phosphate.
SUBUNIT: Homodimer, and homooligomer. Heterodimer with SNX18. Interacts with ITCH. Interacts (via SH3 domain) with TNK2, WASL and ARP3. Identified in a complex with TNK2 and clathrin heavy chains. Identified in a complex with the AP-2 complex, clathrin and DNM2. Interacts (via SH3 domain) with DNM1 and DNM2. Identified in an oligomeric complex containing DNM1 and SNX9.
INTERACTION: P48023:FASLG; NbExp=2; IntAct=EBI-77848, EBI-495538; Q07889:SOS1; NbExp=2; IntAct=EBI-77848, EBI-297487; Q07890:SOS2; NbExp=2; IntAct=EBI-77848, EBI-298181; Q17R13:TNK2 (xeno); NbExp=5; IntAct=EBI-77848, EBI-457220;
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin- coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Note=Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
DOMAIN: The PX domain mediates interaction with membranes enriched in phosphatidylinositol phosphate. Has high affinity for phosphatidylinositol 4,5-bisphosphate, but can also bind to membranes enriched in other phosphatidylinositol phosphates.
PTM: Ubiquitinated by ITCH.
PTM: Phosphorylated on tyrosine residues by TNK2. Phosphorylation promotes its activity in the degradation of EGFR.
SIMILARITY: Belongs to the sorting nexin family.
SIMILARITY: Contains 1 BAR domain.
SIMILARITY: Contains 1 PX (phox homology) domain.
SIMILARITY: Contains 1 SH3 domain.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001683 - Phox
IPR001452 - SH3_domain
IPR014536 - Snx9
IPR019497 - Sorting_nexin_WASP-bd-dom

Pfam Domains:
PF10456 - WASP-binding domain of Sorting nexin protein
PF00787 - PX domain
PF00018 - SH3 domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2RAI
- X-ray

2RAJ
- X-ray

2RAK
- X-ray
To conserve bandwidth, only the images from the first 3 structures are shown.
3DYT - X-ray 3DYU - X-ray 3LGE - X-ray


ModBase Predicted Comparative 3D Structure on Q9Y5X1
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+  Other Names for This Gene
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+  Methods, Credits, and Use Restrictions
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