Human Gene LGALS3BP (ENST00000262776.8) Description and Page Index

Description: Homo sapiens galectin 3 binding protein (LGALS3BP), mRNA. (from RefSeq NM_005567)
Gencode Transcript: ENST00000262776.8
Gencode Gene: ENSG00000108679.13
Transcript (Including UTRs)
Position: hg38 chr17:78,971,255-78,979,923 Size: 8,669 Total Exon Count: 6 Strand: -
Coding Region
Position: hg38 chr17:78,971,576-78,977,191 Size: 5,616 Coding Exon Count: 5

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: LG3BP_HUMAN DESCRIPTION: RecName: Full=Galectin-3-binding protein; AltName: Full=Basement membrane autoantigen p105; AltName: Full=Lectin galactoside-binding soluble 3-binding protein; AltName: Full=Mac-2-binding protein; Short=MAC2BP; Short=Mac-2 BP; AltName: Full=Tumor-associated antigen 90K; Flags: Precursor; FUNCTION: Promotes intergrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells. SUBUNIT: Homodimers and homomultimers. The multimers form ring- like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID. SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space, extracellular matrix. TISSUE SPECIFICITY: Ubiquitous. Detected in body fluids such as semen, milk, serum, tears, saliva and urine. Expressed by keratinocytes and fibroblasts. SIMILARITY: Contains 1 BACK (BTB/Kelch associated) domain. SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 1 SRCR domain.