ID:JADE1_HUMAN DESCRIPTION: RecName: Full=Protein Jade-1; AltName: Full=PHD finger protein 17; FUNCTION: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. SUBUNIT: Component of the HBO1 complex composed at least of ING4 or ING5, KAT7/HBO1, MEAF6, and one of PHF15, PHF16 and PHF17. Isoform 3 interacts with VHL and KAT5. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Highly expressed in kidney. Also present in pancreas, liver and heart (at protein level). Down-regulated in renal cancer cells. DOMAIN: The 2 PHD-type zinc fingers are required for transcriptional activity. SIMILARITY: Belongs to the JADE family. SIMILARITY: Contains 2 PHD-type zinc fingers. SEQUENCE CAUTION: Sequence=BAB15371.1; Type=Erroneous initiation; Sequence=BAC11335.1; Type=Erroneous initiation;
ModBase Predicted Comparative 3D Structure on Q6IE81
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