ID:TLE3_HUMAN DESCRIPTION: RecName: Full=Transducin-like enhancer protein 3; AltName: Full=Enhancer of split groucho-like protein 3; Short=ESG3; FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). SUBUNIT: Homotetramer and heterooligomer with other family members. Binds LEF1, TCF7 and TCF7L1 (By similarity). Binds FOXA2. Interacts with XIAP/BIRC4 and TCF7L2/TCF4. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Placenta and lung. PTM: Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4. SIMILARITY: Belongs to the WD repeat Groucho/TLE family. SIMILARITY: Contains 7 WD repeats. SEQUENCE CAUTION: Sequence=BAB13373.1; Type=Erroneous initiation;
ModBase Predicted Comparative 3D Structure on Q04726
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