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Comments and Description Text from UniProtKB
ID:CD14_HUMAN DESCRIPTION: RecName: Full=Monocyte differentiation antigen CD14; AltName: Full=Myeloid cell-specific leucine-rich glycoprotein; AltName: CD_antigen=CD14; Contains: RecName: Full=Monocyte differentiation antigen CD14, urinary form; Contains: RecName: Full=Monocyte differentiation antigen CD14, membrane-bound form; Flags: Precursor; FUNCTION: Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules. SUBUNIT: Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. TISSUE SPECIFICITY: Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages. PTM: N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. SIMILARITY: Contains 11 LRR (leucine-rich) repeats. WEB RESOURCE: Name=Wikipedia; Note=CD14 entry; URL="http://en.wikipedia.org/wiki/CD14";
Protein Domain and Structure Information
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Other Names for This Gene
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
