Human Gene FARSA (ENST00000423140.6) Description and Page Index
  Description: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). (from UniProt Q9Y285)
Gencode Transcript: ENST00000423140.6
Gencode Gene: ENSG00000179115.11
Transcript (Including UTRs)
   Position: hg38 chr19:12,922,480-12,933,714 Size: 11,235 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg38 chr19:12,922,748-12,933,696 Size: 10,949 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther NamesMethods
Data last updated at UCSC: 2021-06-20 19:51:40

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:12,922,480-12,933,714)mRNA (may differ from genome)Protein (477 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaExonPrimerGeneCards
HGNCMGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: SYFA_HUMAN
DESCRIPTION: RecName: Full=Phenylalanine--tRNA ligase alpha subunit; EC=6.1.1.20; AltName: Full=CML33; AltName: Full=Phenylalanyl-tRNA synthetase alpha subunit; Short=PheRS;
CATALYTIC ACTIVITY: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe).
SUBUNIT: Tetramer of two alpha and two beta subunits (By similarity).
INTERACTION: Q9BQ95:ECSIT; NbExp=2; IntAct=EBI-725361, EBI-712452;
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
SEQUENCE CAUTION: Sequence=AAB51175.1; Type=Erroneous gene model prediction;

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006195 - aa-tRNA-synth_II
IPR004529 - Phe-tRNA-synth_IIc_asu
IPR002319 - Phenylalanyl-tRNA_Synthase
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF01409 - tRNA synthetases class II core domain (F)

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3L4G - X-ray


ModBase Predicted Comparative 3D Structure on Q9Y285
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-  Other Names for This Gene
  UCSC ID: ENST00000423140.6
Representative RNA: AK304587
Protein: Q9Y285 (aka SYFA_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.