Human Gene ARHGEF7 (ENST00000375739.6) Description and Page Index

Description: Homo sapiens Rho guanine nucleotide exchange factor 7 (ARHGEF7), transcript variant 4, mRNA. (from RefSeq NM_001113512)
Gencode Transcript: ENST00000375739.6
Gencode Gene: ENSG00000102606.18
Transcript (Including UTRs)
Position: hg38 chr13:111,115,277-111,295,195 Size: 179,919 Total Exon Count: 18 Strand: +
Coding Region
Position: hg38 chr13:111,115,527-111,292,332 Size: 176,806 Coding Exon Count: 18

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: ARHG7_HUMAN DESCRIPTION: RecName: Full=Rho guanine nucleotide exchange factor 7; AltName: Full=Beta-Pix; AltName: Full=COOL-1; AltName: Full=PAK-interacting exchange factor beta; AltName: Full=p85; FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. SUBUNIT: Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1 and RAC1. Interacts with ITCH (By similarity). Interacts with unphosphorylated PAK1. Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis. Interacts with FRMPD4 (via N-terminus). Interacts with CaMK1. INTERACTION: Q9Y2X7:GIT1; NbExp=2; IntAct=EBI-717515, EBI-466061; P41227:NAA10; NbExp=3; IntAct=EBI-717515, EBI-747693; SUBCELLULAR LOCATION: Cell junction, focal adhesion (By similarity). Cell projection, ruffle (By similarity). Cytoplasm, cell cortex (By similarity). Note=Detected at cell adhesions. A small proportion is detected at focal adhesions. PTM: Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1. SIMILARITY: Contains 1 CH (calponin-homology) domain. SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=AAH50521.1; Type=Erroneous initiation; Sequence=BAA09763.2; Type=Erroneous initiation; Sequence=CAD38906.1; Type=Erroneous initiation;