ID:SP100_HUMAN DESCRIPTION: RecName: Full=Nuclear autoantigen Sp-100; AltName: Full=Lysp100b; AltName: Full=Nuclear dot-associated Sp100 protein; AltName: Full=Speckled 100 kDa; FUNCTION: May play a role in the control of gene expression. SUBUNIT: Homodimer. Splice variants heterodimerize. Interacts with members of the HP1 family of nonhistone chromosomal protein, such as CBX5 and CBX3 via the PxVxL motif. Interacts with Epstein-Barr virus EBNA-LP. Interacts with human cytomegalovirus/HHV-5 protein UL123. INTERACTION: P55854:SUMO3; NbExp=2; IntAct=EBI-751145, EBI-474067; SUBCELLULAR LOCATION: Nucleus, PML body. Note=Found in the nuclear body, also known as nuclear domain 10 (ND10), PML oncogenic domain (POD), nuclear dots (ND) and KR body. The nuclear body is a nucleoplasmic structure of punctate shape, which varies in size and number. Induction by interferon and may be cell cycle stages modulate the subnuclear localization of the isoforms. TISSUE SPECIFICITY: Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines. INDUCTION: By interferon. DOMAIN: The HSR domain is important for the nuclear body targeting as well as for the dimerization. DOMAIN: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain. PTM: Sumoylated. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting. MISCELLANEOUS: The major isoform Sp100-A, has a calculated MW of 54 kDa, but exhibits aberrant electrophoretic mobilities, with an apparent MW OF 100 kDa. SIMILARITY: Contains 2 HMG box DNA-binding domains. SIMILARITY: Contains 1 HSR domain. SIMILARITY: Contains 1 SAND domain.
ModBase Predicted Comparative 3D Structure on P23497
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