Human Gene GNAI1 (ENST00000648476.1) Description and Page Index
Description: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. (from UniProt P63096) Gencode Transcript: ENST00000648476.1 Gencode Gene: ENSG00000127955.17 Transcript (Including UTRs) Position: hg38 chr7:80,133,839-80,219,356 Size: 85,518 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr7:80,135,161-80,217,493 Size: 82,333 Coding Exon Count: 8
Press "+" in the title bar above to open this section.
Comments and Description Text from UniProtKB
ID:GNAI1_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein G(i) subunit alpha-1; AltName: Full=Adenylate cyclase-inhibiting G alpha protein; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division. SUBUNIT: Interacts with GPSM1. Interacts with RGS12. Interacts (via active GTP- or inactive GDP-bound forms) with RGS14 (via RGS and GoLoco domains); the interaction occurs in the centrosomes. Interacts (GDP-bound form) with RIC8A (via C-terminus) (By similarity). Interacts with DRD2. G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. INTERACTION: P81274:GPSM2; NbExp=3; IntAct=EBI-618639, EBI-618655; Q14980:NUMA1; NbExp=4; IntAct=EBI-618639, EBI-521611; SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm. Cell membrane. Cytoplasm, cytoskeleton, centrosome. Note=Localized at the plasma membrane throughout mitosis. Colocalizes with RIC8A and RGS14 at the plasma membrane (By similarity). Localizes in the centrosomes of interphase and mitotic cells, but not in centrosomes during cytokinesis. Detected at the cleavage furrow or the midbody. SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
ModBase Predicted Comparative 3D Structure on P63096
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
