Human Gene ARHGEF28 (ENST00000545377.5) Description and Page Index

Description: Homo sapiens Rho guanine nucleotide exchange factor 28 (ARHGEF28), transcript variant 1, mRNA. (from RefSeq NM_001080479)
Gencode Transcript: ENST00000545377.5
Gencode Gene: ENSG00000214944.9
Transcript (Including UTRs)
Position: hg38 chr5:73,626,158-73,941,992 Size: 315,835 Total Exon Count: 37 Strand: +
Coding Region
Position: hg38 chr5:73,684,852-73,941,013 Size: 256,162 Coding Exon Count: 36

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: ARG28_HUMAN DESCRIPTION: RecName: Full=Rho guanine nucleotide exchange factor 28; AltName: Full=190 kDa guanine nucleotide exchange factor; Short=p190-RhoGEF; Short=p190RhoGEF; AltName: Full=Rho guanine nucleotide exchange factor; FUNCTION: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity). SUBUNIT: Homooligomer; forms cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA. Interacts with microtubules. Interacts with YWHAE and YWHAH. Interacts with PTK2/FAK1. Interacts with NEFL (By similarity). Interacts with CTNND2; prevents interaction with RHOA. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with the microtubule radial and cortical systems (By similarity). PTM: Phosphorylated on tyrosine upon stimulation of cells by laminin (By similarity). SIMILARITY: Contains 1 DH (DBL-homology) domain. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 phorbol-ester/DAG-type zinc finger. SEQUENCE CAUTION: Sequence=AAH12946.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAB15243.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC02707.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000219 - DH-domain
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology
IPR002219 - Prot_Kinase_C-like_PE/DAG-bd
IPR015721 - RhoGEF-like

Pfam Domains:
PF00130 - Phorbol esters/diacylglycerol binding domain (C1 domain)
PF00621 - RhoGEF domain

ModBase Predicted Comparative 3D Structure on Q8N1W1


Front	Top	Side

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