Human Gene IRF7 (ENST00000525445.6) Description and Page Index
  Description: Homo sapiens interferon regulatory factor 7 (IRF7), transcript variant a, mRNA. (from RefSeq NM_001572)
Gencode Transcript: ENST00000525445.6
Gencode Gene: ENSG00000185507.21
Transcript (Including UTRs)
   Position: hg38 chr11:612,555-615,950 Size: 3,396 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg38 chr11:612,645-615,364 Size: 2,720 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther NamesMethods
Data last updated at UCSC: 2021-06-20 19:51:40

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-  Comments and Description Text from UniProtKB
  ID: IRF7_HUMAN
DESCRIPTION: RecName: Full=Interferon regulatory factor 7; Short=IRF-7;
FUNCTION: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages.
ENZYME REGULATION: In the absence of viral infection, maintained as a monomer in an autoinhibited state and phosphorylation disrupts this autoinhibition leading to the liberation of the DNA- binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes.
SUBUNIT: Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1; this interaction leads to the proteasome- dependent degradation of IRF7. Interacts with Epstein-Barr virus LF2. Interacts with MYD88 AND TRAF6.
INTERACTION: O00170:AIP; NbExp=2; IntAct=EBI-968267, EBI-704197; P10398:ARAF; NbExp=2; IntAct=EBI-968267, EBI-365961; Q96A33:CCDC47; NbExp=2; IntAct=EBI-968267, EBI-720151; P51617:IRAK1; NbExp=2; IntAct=EBI-968267, EBI-358664; O94822:LTN1; NbExp=2; IntAct=EBI-968267, EBI-1044684; Q9ULE6:PALD; NbExp=2; IntAct=EBI-968267, EBI-3957166; Q86UE8:TLK2; NbExp=2; IntAct=EBI-968267, EBI-1047967; Q9BVS5:TRMT61B; NbExp=2; IntAct=EBI-968267, EBI-3197877;
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=The phosphorylated and active form accumulates selectively in the nucleus.
TISSUE SPECIFICITY: Expressed predominantly in spleen, thymus and peripheral blood leukocytes.
INDUCTION: By type I interferon (IFN) and viruses.
PTM: Acetylation inhibits its DNA-binding ability and activity.
PTM: In response to a viral infection, phosphorylated on Ser-477 and Ser-479 by TBK1 and IKBKE1. Phosphorylation, and subsequent activation is inhibited by vaccinia virus protein E3. In TLR7- and TLR9-mediated signaling pathway, phosphorylated by IRAK1.
PTM: TRAF6-mediated ubiquitination is required for IRF7 activation (By similarity).
PTM: Sumoylated by TRIM28, which inhibits its transactivation activity.
SIMILARITY: Belongs to the IRF family.
SIMILARITY: Contains 1 IRF tryptophan pentad repeat DNA-binding domain.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019817 - Interferon_reg_fac_CS
IPR001346 - Interferon_reg_fact_DNA-bd_dom
IPR019471 - Interferon_reg_factor-3
IPR017855 - SMAD_dom-like
IPR008984 - SMAD_FHA_domain
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00605 - Interferon regulatory factor transcription factor
PF10401 - Interferon-regulatory factor 3

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2O61 - X-ray


ModBase Predicted Comparative 3D Structure on Q92985
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-  Other Names for This Gene
  UCSC ID: ENST00000525445.6
Representative RNA: NM_001572
Protein: Q92985 (aka IRF7_HUMAN)

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