Human Gene CAPG (ENST00000409921.5) Description and Page Index
  Description: Homo sapiens capping actin protein, gelsolin like (CAPG), transcript variant 3, mRNA. (from RefSeq NM_001256140)
Gencode Transcript: ENST00000409921.5
Gencode Gene: ENSG00000042493.16
Transcript (Including UTRs)
   Position: hg38 chr2:85,394,767-85,410,370 Size: 15,604 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg38 chr2:85,394,893-85,402,145 Size: 7,253 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther NamesMethods
Data last updated at UCSC: 2021-06-20 19:51:40

+  Sequence and Links to Tools and Databases
  Press "+" in the title bar above to open this section.

-  Comments and Description Text from UniProtKB
  ID: CAPG_HUMAN
DESCRIPTION: RecName: Full=Macrophage-capping protein; AltName: Full=Actin regulatory protein CAP-G;
FUNCTION: Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
TISSUE SPECIFICITY: Macrophages and macrophage-like cells.
PTM: The N-terminus is blocked.
SIMILARITY: Belongs to the villin/gelsolin family.
SIMILARITY: Contains 3 gelsolin-like repeats.
CAUTION: This protein was originally thought to be a DNA-binding protein with a helix-loop-helix domain.

+  Protein Domain and Structure Information
  Press "+" in the title bar above to open this section.

-  Other Names for This Gene
  UCSC ID: ENST00000409921.5
Representative RNA: NM_001256140
Protein: P40121 (aka CAPG_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.