Human Gene GPX4 (ENST00000611653.4) Description and Page Index

Description: Homo sapiens glutathione peroxidase 4 (GPX4), transcript variant 4, mRNA. (from RefSeq NM_001367832)
Gencode Transcript: ENST00000611653.4
Gencode Gene: ENSG00000167468.18
Transcript (Including UTRs)
Position: hg38 chr19:1,104,052-1,106,779 Size: 2,728 Total Exon Count: 7 Strand: +
Coding Region
Position: hg38 chr19:1,104,125-1,106,572 Size: 2,448 Coding Exon Count: 7

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: GPX4_HUMAN DESCRIPTION: RecName: Full=Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Short=PHGPx; EC=1.11.1.12; AltName: Full=Glutathione peroxidase 4; Short=GPx-4; Short=GSHPx-4; Flags: Precursor; FUNCTION: Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). CATALYTIC ACTIVITY: 2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O. SUBUNIT: Monomer. Has a tendency to form higher mass oligomers. SUBCELLULAR LOCATION: Isoform Mitochondrial: Mitochondrion. SUBCELLULAR LOCATION: Isoform Cytoplasmic: Cytoplasm. TISSUE SPECIFICITY: Present primarily in testis. SIMILARITY: Belongs to the glutathione peroxidase family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gpx4/";