Press "+" in the title bar above to open this section.
Comments and Description Text from UniProtKB
ID:MED29_HUMAN DESCRIPTION: RecName: Full=Mediator of RNA polymerase II transcription subunit 29; AltName: Full=Intersex-like protein; AltName: Full=Mediator complex subunit 29; FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. SUBUNIT: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Associates with the MED18/MED20 heteromer. INTERACTION: Q9H944:MED20; NbExp=5; IntAct=EBI-394656, EBI-394644; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Widely expressed in embryo and adult. SIMILARITY: Belongs to the Mediator complex subunit 29 family. SEQUENCE CAUTION: Sequence=AAU43732.1; Type=Erroneous initiation;
ModBase Predicted Comparative 3D Structure on Q9NX70
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
