ID:RHOU_HUMAN DESCRIPTION: RecName: Full=Rho-related GTP-binding protein RhoU; AltName: Full=CDC42-like GTPase 1; AltName: Full=GTP-binding protein-like 1; AltName: Full=Rho GTPase-like protein ARHU; AltName: Full=Ryu GTPase; AltName: Full=Wnt-1 responsive Cdc42 homolog 1; Short=WRCH-1; FUNCTION: Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP- bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. COFACTOR: Magnesium. SUBUNIT: Interacts with PAK3. Interacts with ARHGAP30 in a GTP- independent manner. In its GTP-loaded conformation, interacts with ARHGAP31. Interacts with PTK2B/PYK2. INTERACTION: O43639:NCK2; NbExp=4; IntAct=EBI-1638043, EBI-713635; Q13153-2:PAK1; NbExp=2; IntAct=EBI-1638043, EBI-1019502; Q14289:PTK2B; NbExp=4; IntAct=EBI-1638043, EBI-298640; SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor. Cell junction, focal adhesion. Cell projection, podosome. Note=Localizes to podosomes in SRC-transformed cells. TISSUE SPECIFICITY: Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta. PTM: Tyrosine phosphorylated by SRC in response to PTK2B/PYK2 activation. SIMILARITY: Belongs to the small GTPase superfamily. Rho family.
ModBase Predicted Comparative 3D Structure on Q7L0Q8
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