Human Gene VHLL (ENST00000339922.5) Description and Page Index

Description: Homo sapiens VHL like (VHLL), mRNA. (from RefSeq NM_001004319)
Gencode Transcript: ENST00000339922.5
Gencode Gene: ENSG00000189030.10
Transcript (Including UTRs)
Position: hg38 chr1:156,298,624-156,299,307 Size: 684 Total Exon Count: 1 Strand: -
Coding Region
Position: hg38 chr1:156,298,770-156,299,189 Size: 420 Coding Exon Count: 1

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: VHLL_HUMAN DESCRIPTION: RecName: Full=Von Hippel-Lindau-like protein; Short=VHL-like protein; Short=VLP; FUNCTION: Functions as a dominant-negative VHL to serve as a protector of HIFalpha. SUBUNIT: Interacts via the beta domain with the ODD domain of HIF1A This interaction is independent of prolyl hydroxylation of HIF1A. TISSUE SPECIFICITY: Abundantly expressed in the placenta. MISCELLANEOUS: Has little or no E3 ubiquitin ligase activity as it lacks the alpha domain required for nucleating the multiprotein E3 ubiquitin ligase complex.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR002714 - Tumour_suppress_VHL-disease
IPR024053 - VHL_beta_dom
IPR022772 - VHL_tumour_suppress_b/a_dom

Pfam Domains:
PF01847 - VHL beta domain

ModBase Predicted Comparative 3D Structure on Q6RSH7


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