Human Gene ITGB6 (ENST00000283249.7) Description and Page Index
  Description: Homo sapiens integrin subunit beta 6 (ITGB6), transcript variant 6, mRNA. (from RefSeq NM_001282389)
Gencode Transcript: ENST00000283249.7
Gencode Gene: ENSG00000115221.12
Transcript (Including UTRs)
   Position: hg38 chr2:160,099,671-160,200,272 Size: 100,602 Total Exon Count: 15 Strand: -
Coding Region
   Position: hg38 chr2:160,101,736-160,200,063 Size: 98,328 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther NamesMethods
Data last updated at UCSC: 2021-06-20 19:51:40

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:160,099,671-160,200,272)mRNA (may differ from genome)Protein (788 aa)
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HGNCMGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ITB6_HUMAN
DESCRIPTION: RecName: Full=Integrin beta-6; Flags: Precursor;
FUNCTION: Integrin alpha-V/beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion.
SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-6 associates with alpha-V. Interacts with FLNB. Interacts with HAX1. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein, coxsackievirus A9, coxsackievirus B1 capsid proteins and acts as a receptor for these viruses.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: Belongs to the integrin beta chain family.
SIMILARITY: Contains 1 VWFA domain.

+  Protein Domain and Structure Information
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-  Other Names for This Gene
  UCSC ID: ENST00000283249.7
Representative RNA: NM_001282389
Protein: P18564 (aka ITB6_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.