Human Gene ATG4B (ENST00000404914.8) Description and Page Index

Description: Homo sapiens autophagy related 4B cysteine peptidase (ATG4B), transcript variant 1, mRNA. (from RefSeq NM_013325)
Gencode Transcript: ENST00000404914.8
Gencode Gene: ENSG00000168397.17
Transcript (Including UTRs)
Position: hg38 chr2:241,637,693-241,673,857 Size: 36,165 Total Exon Count: 13 Strand: +
Coding Region
Position: hg38 chr2:241,637,715-241,672,264 Size: 34,550 Coding Exon Count: 13

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: ATG4B_HUMAN DESCRIPTION: RecName: Full=Cysteine protease ATG4B; EC=3.4.22.-; AltName: Full=AUT-like 1 cysteine endopeptidase; AltName: Full=Autophagin-1; AltName: Full=Autophagy-related cysteine endopeptidase 1; AltName: Full=Autophagy-related protein 4 homolog B; Short=hAPG4B; FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminal part of MAP1LC3, GABARAPL1, GABARAPL2 and GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Also mediates the lipid deconjugation required for target recycling. ENZYME REGULATION: Inhibited by N-ethylmaleimide. INTERACTION: O95166:GABARAP; NbExp=8; IntAct=EBI-712014, EBI-712001; Q9H0R8:GABARAPL1; NbExp=7; IntAct=EBI-712014, EBI-746969; P60520:GABARAPL2; NbExp=5; IntAct=EBI-712014, EBI-720116; Q9GZQ8:MAP1LC3B; NbExp=6; IntAct=EBI-712014, EBI-373144; SUBCELLULAR LOCATION: Cytoplasm (Probable). TISSUE SPECIFICITY: Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas. SIMILARITY: Belongs to the peptidase C54 family. SEQUENCE CAUTION: Sequence=BAA76787.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC86110.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR005078 - Peptidase_C54

Pfam Domains:
PF03416 - Peptidase family C54

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2CY7 - X-ray	2D1I - X-ray	2Z0D - X-ray
To conserve bandwidth, only the images from the first 3 structures are shown.
2Z0E - X-ray	2ZZP - X-ray

ModBase Predicted Comparative 3D Structure on Q9Y4P1


Front	Top	Side

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