Human Gene HSPH1 (ENST00000630972.2) Description and Page Index

Description: Homo sapiens heat shock protein family H (Hsp110) member 1 (HSPH1), transcript variant 3, mRNA. (from RefSeq NM_001286504)
Gencode Transcript: ENST00000630972.2
Gencode Gene: ENSG00000120694.20
Transcript (Including UTRs)
Position: hg38 chr13:31,136,625-31,162,388 Size: 25,764 Total Exon Count: 18 Strand: -
Coding Region
Position: hg38 chr13:31,137,318-31,162,094 Size: 24,777 Coding Exon Count: 18

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: HS105_HUMAN DESCRIPTION: RecName: Full=Heat shock protein 105 kDa; AltName: Full=Antigen NY-CO-25; AltName: Full=Heat shock 110 kDa protein; FUNCTION: Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity). SUBUNIT: Interacts with HSPA8/HSC70 (By similarity). SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells. PTM: Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity (By similarity). SIMILARITY: Belongs to the heat shock protein 70 family. SEQUENCE CAUTION: Sequence=AAC18044.1; Type=Erroneous initiation; Sequence=BAA13192.2; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/HSPH1ID40891ch13q12.html";