Human Gene LAS1L (ENST00000374811.8) Description and Page Index
  Description: Homo sapiens LAS1 like ribosome biogenesis factor (LAS1L), transcript variant 1, mRNA. (from RefSeq NM_031206)
Gencode Transcript: ENST00000374811.8
Gencode Gene: ENSG00000001497.18
Transcript (Including UTRs)
   Position: hg38 chrX:65,512,582-65,534,787 Size: 22,206 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg38 chrX:65,512,775-65,534,715 Size: 21,941 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther NamesMethods
Data last updated at UCSC: 2021-06-20 19:51:40

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:65,512,582-65,534,787)mRNA (may differ from genome)Protein (734 aa)
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-  Comments and Description Text from UniProtKB
  ID: LAS1L_HUMAN
DESCRIPTION: RecName: Full=Ribosomal biogenesis protein LAS1L; AltName: Full=Protein LAS1 homolog;
FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA.
SUBUNIT: Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.
INTERACTION: Q96T60:PNKP; NbExp=1; IntAct=EBI-1051591, EBI-1045072;
SUBCELLULAR LOCATION: Nucleus, nucleolus. Note=localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export.
SIMILARITY: Belongs to the LAS1 family.
SEQUENCE CAUTION: Sequence=BAB84913.1; Type=Erroneous initiation;

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