ID:RFX4_HUMAN DESCRIPTION: RecName: Full=Transcription factor RFX4; AltName: Full=Regulatory factor X 4; AltName: Full=Testis development protein NYD-SP10; FUNCTION: May activate transcription by interacting directly with the X-box (By similarity). SUBUNIT: Homodimer. Heterodimer with RFX2 and RFX3. Binds DNA. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Isoform 4 is testis-specific. Isoform 1 is expressed in brain and gliomas. Isoform 2 and isoform 3 are testis-specific (at protein level). Isoform 1 is expressed in brain (at protein level). Isoform 3 is expressed at a higher level in adult testes and ejaculated spematozoa than in fetal testes. SIMILARITY: Belongs to the RFX family. SIMILARITY: Contains 1 RFX-type winged-helix DNA-binding domain. SEQUENCE CAUTION: Sequence=BAB59001.1; Type=Miscellaneous discrepancy; Note=Probable intron retention; Sequence=BAC11288.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE48237.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=BAE48238.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Protein Domain and Structure Information
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