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Comments and Description Text from UniProtKB
ID:GDPD5_HUMAN DESCRIPTION: RecName: Full=Glycerophosphodiester phosphodiesterase domain-containing protein 5; EC=3.1.-.-; AltName: Full=Glycerophosphodiester phosphodiesterase 2; FUNCTION: Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine. SUBUNIT: Interacts with PRDX1; forms a mixed-disulfide with PRDX1, leading to disrupt intramolecular disulfide bond between Cys-25 and Cys-571 (By similarity). SUBCELLULAR LOCATION: Endomembrane system; Multi-pass membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Cell projection, growth cone (By similarity). Note=In a punctate perinuclear pattern (By similarity). PTM: Intramolecular disulfide bond between Cys-25 and Cys-571 is reduced by PRDX1 (By similarity). SIMILARITY: Belongs to the glycerophosphoryl diester phosphodiesterase family. SIMILARITY: Contains 1 GDPD domain. SEQUENCE CAUTION: Sequence=AAP97686.1; Type=Erroneous initiation; Sequence=BAC11242.1; Type=Erroneous initiation;
Protein Domain and Structure Information
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