ID:HGF_HUMAN DESCRIPTION: RecName: Full=Hepatocyte growth factor; AltName: Full=Hepatopoietin-A; AltName: Full=Scatter factor; Short=SF; Contains: RecName: Full=Hepatocyte growth factor alpha chain; Contains: RecName: Full=Hepatocyte growth factor beta chain; Flags: Precursor; FUNCTION: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. Activating ligand for the receptor tyrosine kinase MET by binding and promoting its dimerization. SUBUNIT: Dimer of an alpha chain and a beta chain linked by a disulfide bond. INTERACTION: P08581:MET; NbExp=2; IntAct=EBI-1039104, EBI-1039152; P16056:Met (xeno); NbExp=2; IntAct=EBI-1039104, EBI-1798780; DISEASE: Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily. SIMILARITY: Contains 4 kringle domains. SIMILARITY: Contains 1 PAN domain. SIMILARITY: Contains 1 peptidase S1 domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hgf/"; WEB RESOURCE: Name=Wikipedia; Note=Hepatocyte growth factor entry; URL="http://en.wikipedia.org/wiki/Hepatocyte_growth_factor";
Protein Domain and Structure Information
Press "+" in the title bar above to open this section.
Other Names for This Gene
Press "+" in the title bar above to open this section.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.
