Human Gene CD36 (ENST00000435819.5) Description and Page Index

Description: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. (from UniProt P16671)
Gencode Transcript: ENST00000435819.5
Gencode Gene: ENSG00000135218.19
Transcript (Including UTRs)
Position: hg38 chr7:80,369,575-80,674,409 Size: 304,835 Total Exon Count: 17 Strand: +
Coding Region
Position: hg38 chr7:80,646,741-80,674,147 Size: 27,407 Coding Exon Count: 12

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: CD36_HUMAN DESCRIPTION: RecName: Full=Platelet glycoprotein 4; AltName: Full=Fatty acid translocase; Short=FAT; AltName: Full=Glycoprotein IIIb; Short=GPIIIB; AltName: Full=Leukocyte differentiation antigen CD36; AltName: Full=PAS IV; AltName: Full=PAS-4; AltName: Full=Platelet collagen receptor; AltName: Full=Platelet glycoprotein IV; Short=GPIV; AltName: Full=Thrombospondin receptor; AltName: CD_antigen=CD36; FUNCTION: Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. SUBUNIT: Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. PTM: N-glycosylated and O-glycosylated with a ratio of 2:1. POLYMORPHISM: Genetic variations in CD36 are involved in susceptibility to malaria and influence the severity and outcome of malaria infection [MIM:611162]. DISEASE: Defects in CD36 are the cause of platelet glycoprotein IV deficiency (PG4D)[MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. DISEASE: Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938]. SIMILARITY: Belongs to the CD36 family. SEQUENCE CAUTION: Sequence=AAM14636.2; Type=Frameshift; Positions=53; WEB RESOURCE: Name=Wikipedia; Note=CD36 entry; URL="http://en.wikipedia.org/wiki/CD36"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CD36"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cd36/";

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR002159 - CD36
IPR005428 - CD36_antigen

Pfam Domains:
PF01130 - CD36 family

ModBase Predicted Comparative 3D Structure on P16671


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