Human Gene THOC2 (ENST00000355725.8) Description and Page Index
Description: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex.The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. (from UniProt Q8NI27) Gencode Transcript: ENST00000355725.8 Gencode Gene: ENSG00000125676.20 Transcript (Including UTRs) Position: hg38 chrX:123,610,198-123,733,056 Size: 122,859 Total Exon Count: 39 Strand: - Coding Region Position: hg38 chrX:123,610,936-123,733,022 Size: 122,087 Coding Exon Count: 38
ID:THOC2_HUMAN DESCRIPTION: RecName: Full=THO complex subunit 2; Short=Tho2; AltName: Full=hTREX120; FUNCTION: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex.The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. SUBUNIT: Component of the THO complex, which is composed of THOC1, THOC2, THOC5, THOC6 and THOC7. Together with THOC3, ALYREF/THOC4 and DDX39B, THO forms the transcription/export (TREX) complex. Interacts with THOC1. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the THOC2 family. SEQUENCE CAUTION: Sequence=AAM28436.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part; Sequence=BAB14630.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Pfam Domains: PF11262 - Transcription factor/nuclear export subunit protein 2 PF11732 - Transcription- and export-related complex subunit
ModBase Predicted Comparative 3D Structure on Q8NI27
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