ID:FCG2B_HUMAN DESCRIPTION: RecName: Full=Low affinity immunoglobulin gamma Fc region receptor II-b; Short=IgG Fc receptor II-b; AltName: Full=CDw32; AltName: Full=Fc-gamma RII-b; Short=Fc-gamma-RIIb; Short=FcRII-b; AltName: CD_antigen=CD32; Flags: Precursor; FUNCTION: Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B- cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. SUBUNIT: Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN. INTERACTION: P01857:IGHG1; NbExp=31; IntAct=EBI-724784, EBI-356114; P16333:NCK1; NbExp=2; IntAct=EBI-724784, EBI-389883; P19174:PLCG1; NbExp=2; IntAct=EBI-724784, EBI-79387; SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Is the most broadly distributed Fc-gamma- receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases. PTM: Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK. POLYMORPHISM: Note=FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIM:611162]. DISEASE: Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression. DISEASE: Defects in FCGR2B are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. CAUTION: Has sometimes been attributed to correspond to FcR-IIC. SEQUENCE CAUTION: Sequence=CAA35645.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/FCGR2BID397.html";
ModBase Predicted Comparative 3D Structure on P31994
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