Human Gene LPA (ENST00000447678.2) Description and Page Index

Description: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. (from UniProt P08519)
Gencode Transcript: ENST00000447678.2
Gencode Gene: ENSG00000198670.12
Transcript (Including UTRs)
Position: hg38 chr6:160,586,480-160,613,115 Size: 26,636 Total Exon Count: 11 Strand: -
Coding Region
Position: hg38 chr6:160,586,480-160,613,115 Size: 26,636 Coding Exon Count: 11

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: APOA_HUMAN DESCRIPTION: RecName: Full=Apolipoprotein(a); Short=Apo(a); Short=Lp(a); EC=3.4.21.-; Flags: Precursor; FUNCTION: Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330. SUBUNIT: Disulfide-linked to apo-B100. Binds to fibronectin and decorin. PTM: N- and O-glycosylated. The N-glycans are complex biantennary structures present in either a mono- or disialylated state. The O- glycans are mostly (80%) represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated and non-sialylated O-glycans also detected. POLYMORPHISM: The reference genome sequence encodes a variant that contains 16 Kringle domains and that lack residues 533 to 3040. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 38 copies of the kringle-type repeats. MISCELLANEOUS: Apo(a) is known to be proteolytically cleaved, leading to the formation of the so-called mini-Lp(a). Apo(a) fragments accumulate in atherosclerotic lesions, where they may promote thrombogenesis. O-glycosylation may limit the extent of proteolytic fragmentation. Homology with plasminogen kringles IV and V is thought to underlie the atherogenicity of the protein, because the fragments are competing with plasminogen for fibrin(ogen) binding. SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily. SIMILARITY: Contains 38 kringle domains. SIMILARITY: Contains 1 peptidase S1 domain. WEB RESOURCE: Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=APOA";

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000001 - Kringle
IPR013806 - Kringle-like
IPR018056 - Kringle_CS
IPR009003 - Pept_cys/ser_Trypsin-like
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A

Pfam Domains:
PF00051 - Kringle domain
PF00089 - Trypsin

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1I71 - X-ray	1JFN - NMR	1KIV - X-ray
To conserve bandwidth, only the images from the first 3 structures are shown.
2FEB - NMR	3KIV - X-ray	4KIV - X-ray

ModBase Predicted Comparative 3D Structure on P08519


Front	Top	Side

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