Human Gene CPD (ENST00000225719.9) Description and Page Index

Description: Homo sapiens carboxypeptidase D (CPD), transcript variant 1, mRNA. (from RefSeq NM_001304)
Gencode Transcript: ENST00000225719.9
Gencode Gene: ENSG00000108582.12
Transcript (Including UTRs)
Position: hg38 chr17:30,378,927-30,469,989 Size: 91,063 Total Exon Count: 21 Strand: +
Coding Region
Position: hg38 chr17:30,378,981-30,464,814 Size: 85,834 Coding Exon Count: 21

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: CBPD_HUMAN DESCRIPTION: RecName: Full=Carboxypeptidase D; EC=3.4.17.22; AltName: Full=Metallocarboxypeptidase D; AltName: Full=gp180; Flags: Precursor; CATALYTIC ACTIVITY: Releases C-terminal Arg and Lys from polypeptides. COFACTOR: Binds 2 zinc ions per subunit (By similarity). BIOPHYSICOCHEMICAL PROPERTIES: pH dependence: Optimum pH is 6.0-6.5; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). TISSUE SPECIFICITY: Highly expressed in placenta, pancreas and hepatoma cells. Lower levels found in skeletal muscle, heart and colon carcinoma and melanoma cell lines. DOMAIN: There are 3 carboxypeptidase-like domains. Only the first two domains seem to have kept a catalytic activity. SIMILARITY: Belongs to the peptidase M14 family.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008969 - CarboxyPept-like_regulatory
IPR014766 - CarboxyPept_regulatory_dom
IPR015567 - Pept_M14B_carboxypept_D2
IPR000834 - Peptidase_M14

Pfam Domains:
PF00246 - Zinc carboxypeptidase

ModBase Predicted Comparative 3D Structure on O75976


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.