Human Gene GFRA2 (ENST00000524240.6) Description and Page Index
  Description: Homo sapiens GDNF family receptor alpha 2 (GFRA2), transcript variant 1, mRNA. (from RefSeq NM_001495)
Gencode Transcript: ENST00000524240.6
Gencode Gene: ENSG00000168546.11
Transcript (Including UTRs)
   Position: hg38 chr8:21,690,398-21,788,875 Size: 98,478 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg38 chr8:21,693,278-21,788,159 Size: 94,882 Coding Exon Count: 9 

Page IndexSequence and LinksUniProtKB CommentsProtein StructureOther NamesMethods
Data last updated at UCSC: 2021-06-20 19:51:40

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:21,690,398-21,788,875)mRNA (may differ from genome)Protein (464 aa)
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HGNCMGIPubMedUniProtKB

-  Comments and Description Text from UniProtKB
  ID: GFRA2_HUMAN
DESCRIPTION: RecName: Full=GDNF family receptor alpha-2; Short=GDNF receptor alpha-2; Short=GDNFR-alpha-2; Short=GFR-alpha-2; AltName: Full=GDNF receptor beta; Short=GDNFR-beta; AltName: Full=Neurturin receptor alpha; Short=NRTNR-alpha; Short=NTNR-alpha; AltName: Full=RET ligand 2; AltName: Full=TGF-beta-related neurotrophic factor receptor 2; Flags: Precursor;
FUNCTION: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity).
TISSUE SPECIFICITY: Isoform 1 is found in both brain and placenta.
SIMILARITY: Belongs to the GDNFR family.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016017 - GDNF/GAS1
IPR003438 - GDNF_rcpt
IPR003504 - GDNF_rcpt_a2
IPR017372 - Glial_neurotroph_fac_rcpt_a1/2

Pfam Domains:
PF02351 - GDNF/GAS1 domain

ModBase Predicted Comparative 3D Structure on O00451
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+  Other Names for This Gene
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+  Methods, Credits, and Use Restrictions
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