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Comments and Description Text from UniProtKB
ID:MAP1A_HUMAN DESCRIPTION: RecName: Full=Microtubule-associated protein 1A; Short=MAP-1A; AltName: Full=Proliferation-related protein p80; Contains: RecName: Full=MAP1A heavy chain; Contains: RecName: Full=MAP1 light chain LC2; FUNCTION: Structural protein involved in the filamentous cross- bridging between microtubules and other skeletal elements. SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Interacts with TIAM2. Interacts with guanylate kinase-like domain of DLG1, DLG2, DLG4. Binds to CSNK1D (By similarity). INTERACTION: Q9NRI5:DISC1; NbExp=3; IntAct=EBI-929047, EBI-529989; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (Probable). TISSUE SPECIFICITY: Brain. DOMAIN: The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules. PTM: Phosphorylated by CSNK1D (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. PTM: LC2 is generated from MAP1A by proteolytic processing. SIMILARITY: Belongs to the MAP1 family.
ModBase Predicted Comparative 3D Structure on P78559
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Other Names for This Gene
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Methods, Credits, and Use Restrictions
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