Human Gene SETD1B (ENST00000619791.1) Description and Page Index

Description: Histone methyltransferase that specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys- 9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overalpping localization with SETD1A suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. Specifically tri-methylates 'Lys-4' of histone H3 in vitro. (from UniProt Q9UPS6)
Gencode Transcript: ENST00000619791.1
Gencode Gene: ENSG00000139718.11
Transcript (Including UTRs)
Position: hg38 chr12:121,804,738-121,830,239 Size: 25,502 Total Exon Count: 16 Strand: +
Coding Region
Position: hg38 chr12:121,804,738-121,830,239 Size: 25,502 Coding Exon Count: 16

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR024657 - COMPASS_Set1_N-SET
IPR015722 - Histone-lysine_MeTfrase
IPR012677 - Nucleotide-bd_a/b_plait
IPR003616 - Post-SET_dom
IPR000504 - RRM_dom
IPR001214 - SET_dom

Pfam Domains:
PF11764 - COMPASS (Complex proteins associated with Set1p) component N
PF00076 - RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
PF00856 - SET domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3UVO - X-ray

4ES0 - X-ray

ModBase Predicted Comparative 3D Structure on Q9UPS6


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