Human Gene BRD1 (ENST00000457780.3) Description and Page Index

Description: Homo sapiens bromodomain containing 1 (BRD1), transcript variant 7, non-coding RNA. (from RefSeq NR_146335)
Gencode Transcript: ENST00000457780.3
Gencode Gene: ENSG00000100425.18
Transcript (Including UTRs)
Position: hg38 chr22:49,773,293-49,824,804 Size: 51,512 Total Exon Count: 12 Strand: -
Coding Region
Position: hg38 chr22:49,774,233-49,824,317 Size: 50,085 Coding Exon Count: 12

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: BRD1_HUMAN DESCRIPTION: RecName: Full=Bromodomain-containing protein 1; AltName: Full=BR140-like protein; AltName: Full=Bromodomain and PHD finger-containing protein 2; FUNCTION: Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. SUBUNIT: Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts (via PHD-type zinc finger domain) with unmodified histone H3. Interacts (via PWWP domain) with dimethylated and trimethylated 'Lys-79' on histone H3. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highly expressed in testis. SIMILARITY: Contains 1 bromo domain. SIMILARITY: Contains 1 PHD-type zinc finger. SIMILARITY: Contains 1 PWWP domain.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001487 - Bromodomain
IPR018359 - Bromodomain_CS
IPR019542 - Enhancer_polycomb-like_N
IPR000313 - PWWP
IPR019786 - Zinc_finger_PHD-type_CS
IPR011011 - Znf_FYVE_PHD
IPR001965 - Znf_PHD
IPR019787 - Znf_PHD-finger
IPR013083 - Znf_RING/FYVE/PHD

Pfam Domains:
PF00439 - Bromodomain
PF10513 - Enhancer of polycomb-like
PF00855 - PWWP domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2KU3 - NMR	2L43 - NMR	3LYI - X-ray
To conserve bandwidth, only the images from the first 3 structures are shown.
3RCW - X-ray

ModBase Predicted Comparative 3D Structure on O95696


Front	Top	Side

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