Human Gene TP53I3 (ENST00000335934.8) Description and Page Index

Description: Homo sapiens tumor protein p53 inducible protein 3 (TP53I3), transcript variant 2, mRNA. (from RefSeq NM_147184)
Gencode Transcript: ENST00000335934.8
Gencode Gene: ENSG00000115129.14
Transcript (Including UTRs)
Position: hg38 chr2:24,077,433-24,085,215 Size: 7,783 Total Exon Count: 6 Strand: -
Coding Region
Position: hg38 chr2:24,077,579-24,084,326 Size: 6,748 Coding Exon Count: 5

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: QORX_HUMAN DESCRIPTION: RecName: Full=Quinone oxidoreductase PIG3; EC=1.-.-.-; AltName: Full=Tumor protein p53-inducible protein 3; AltName: Full=p53-induced gene 3 protein; FUNCTION: May be involved in the generation of reactive oxygen species (ROS). Has low NADPH-dependent beta-naphthoquinone reductase activity, with a preference for 1,2-beta-naphthoquinone over 1,4-beta-naphthoquinone. Has low NADPH-dependent diamine reductase activity (in vitro). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=215 uM for 1,2-naphthoquinone; SUBUNIT: Homodimer. INDUCTION: Isoform 1 and isoform 2 are both activated by p53/TP53, doxorubicin, etoposide and ionizing radiation. Isoform 2 is highly activated by UV radiation. SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. SEQUENCE CAUTION: Sequence=AAC39535.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tp53i3/";

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR013149 - ADH_C
IPR013154 - ADH_GroES-like
IPR002085 - ADH_SF_Zn-type
IPR011032 - GroES-like
IPR016040 - NAD(P)-bd_dom
IPR014189 - Quinone_OxRdtase_PIG3

Pfam Domains:
PF08240 - Alcohol dehydrogenase GroES-like domain
PF00107 - Zinc-binding dehydrogenase

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2J8Z - X-ray

2OBY - X-ray

ModBase Predicted Comparative 3D Structure on Q53FA7


Front	Top	Side

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