Human Gene SYT7 (ENST00000540677.5) Description and Page Index

Description: Homo sapiens synaptotagmin 7 (SYT7), transcript variant 1, mRNA. (from RefSeq NM_001252065)
Gencode Transcript: ENST00000540677.5
Gencode Gene: ENSG00000011347.10
Transcript (Including UTRs)
Position: hg38 chr11:61,518,057-61,580,826 Size: 62,770 Total Exon Count: 10 Strand: -
Coding Region
Position: hg38 chr11:61,518,627-61,580,820 Size: 62,194 Coding Exon Count: 10

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: SYT7_HUMAN DESCRIPTION: RecName: Full=Synaptotagmin-7; AltName: Full=IPCA-7; AltName: Full=Prostate cancer-associated protein 7; AltName: Full=Synaptotagmin VII; Short=SytVII; FUNCTION: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). COFACTOR: Binds 3 calcium ions per subunit. The ions are bound to the C2 domains (By similarity). SUBUNIT: Interacts with SYNCRIP isoform 3 C-terminus (By similarity). SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass membrane protein (By similarity). TISSUE SPECIFICITY: Expressed in a variety of adult and fetal tissues. DOMAIN: The second C2 domain/C2B is responsible for SYNCRIP binding (By similarity). SIMILARITY: Belongs to the synaptotagmin family. SIMILARITY: Contains 2 C2 domains. SEQUENCE CAUTION: Sequence=AAB92667.1; Type=Frameshift; Positions=6, 10, 15;

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000008 - C2_Ca-dep
IPR008973 - C2_Ca/lipid-bd_dom_CaLB
IPR020477 - C2_dom
IPR018029 - C2_membr_targeting
IPR001565 - Synaptotagmin
IPR015427 - Synaptotagmin7

Pfam Domains:
PF00168 - C2 domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2D8K - NMR

ModBase Predicted Comparative 3D Structure on O43581


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