Human Gene ELOC (ENST00000284811.12) Description and Page Index
Description: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). (from UniProt Q15369) Gencode Transcript: ENST00000284811.12 Gencode Gene: ENSG00000154582.17 Transcript (Including UTRs) Position: hg38 chr8:73,946,401-73,972,106 Size: 25,706 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr8:73,946,630-73,959,768 Size: 13,139 Coding Exon Count: 3
ID:ELOC_HUMAN DESCRIPTION: RecName: Full=Transcription elongation factor B polypeptide 1; AltName: Full=Elongin 15 kDa subunit; AltName: Full=Elongin-C; Short=EloC; AltName: Full=RNA polymerase II transcription factor SIII subunit C; AltName: Full=SIII p15; FUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). FUNCTION: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC- box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. SUBUNIT: Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1 (By similarity). The elongin BC complex is part of a complex with hydroxylated HIF1A. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Interacts with TMF1. Interacts with human respiratory syncytial virus (HRSV) protein NS1. INTERACTION: Q96G25:MED8; NbExp=3; IntAct=EBI-301231, EBI-394405; Q99619:SPSB2; NbExp=3; IntAct=EBI-301231, EBI-2323209; Q96A44:SPSB4; NbExp=2; IntAct=EBI-301231, EBI-2323233; Q15370:TCEB2; NbExp=3; IntAct=EBI-301231, EBI-301238; P12504:vif (xeno); NbExp=5; IntAct=EBI-301231, EBI-779991; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Overexpressed in prostate cancer cell line PC- 3 and breast cancer cell line SK-BR-3. SIMILARITY: Belongs to the SKP1 family.
ModBase Predicted Comparative 3D Structure on Q15369
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