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Comments and Description Text from UniProtKB
ID:GPX4_HUMAN DESCRIPTION: RecName: Full=Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Short=PHGPx; EC=1.11.1.12; AltName: Full=Glutathione peroxidase 4; Short=GPx-4; Short=GSHPx-4; Flags: Precursor; FUNCTION: Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity). CATALYTIC ACTIVITY: 2 glutathione + a lipid hydroperoxide = glutathione disulfide + lipid + 2 H(2)O. SUBUNIT: Monomer. Has a tendency to form higher mass oligomers. SUBCELLULAR LOCATION: Isoform Mitochondrial: Mitochondrion. SUBCELLULAR LOCATION: Isoform Cytoplasmic: Cytoplasm. TISSUE SPECIFICITY: Present primarily in testis. SIMILARITY: Belongs to the glutathione peroxidase family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gpx4/";
ModBase Predicted Comparative 3D Structure on P36969
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