Human Gene LLGL2 (ENST00000578363.5) Description and Page Index

Description: Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. (from UniProt Q6P1M3)
Gencode Transcript: ENST00000578363.5
Gencode Gene: ENSG00000073350.14
Transcript (Including UTRs)
Position: hg38 chr17:75,525,779-75,564,723 Size: 38,945 Total Exon Count: 11 Strand: +
Coding Region
Position: hg38 chr17:75,543,427-75,564,542 Size: 21,116 Coding Exon Count: 9

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: L2GL2_HUMAN DESCRIPTION: RecName: Full=Lethal(2) giant larvae protein homolog 2; AltName: Full=HGL; FUNCTION: Part of a complex with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6, which may ensure the correct organization and orientation of bipolar spindles for normal cell division. This complex plays roles in the initial phase of the establishment of epithelial cell polarity. SUBUNIT: Interacts with GPSM2/LGN, PRKCI/aPKC and PARD6B/Par-6. The complex is enhanced during mitosis. SUBCELLULAR LOCATION: Cytoplasm. Note=Localized in the perinuclear structure and faintly at the cell-cell contacts sites in the interphase. Localized at the cell periphery during metaphase. Cortical localization in mitotic cells. Found in the lateral region of polarized epithelial cells. PTM: Phosphorylated at Ser-653 by PRKCI. Phosphorylation is enhanced during cell polarization induced by calcium. Phosphorylation may occur during the cell-cell contact-induced cell polarization and may contribute to the segregation of LLGL2 from the PRKCI/aPKC and PARD6B/Par-6 complex. MISCELLANEOUS: Overexpression of LLGL2 inhibits the tight junction formation. SIMILARITY: Belongs to the WD repeat L(2)GL family. SIMILARITY: Contains 14 WD repeats.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000664 - Lethal2_giant
IPR013577 - LLGL2
IPR015943 - WD40/YVTN_repeat-like_dom
IPR001680 - WD40_repeat
IPR019775 - WD40_repeat_CS
IPR017986 - WD40_repeat_dom

Pfam Domains:
PF08366 - LLGL2
PF00400 - WD domain, G-beta repeat

ModBase Predicted Comparative 3D Structure on Q6P1M3


Front	Top	Side

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