Human Gene RTEL1 (ENST00000508582.6) Description and Page Index

Description: Homo sapiens regulator of telomere elongation helicase 1 (RTEL1), transcript variant 2, mRNA. (from RefSeq NM_032957)
Gencode Transcript: ENST00000508582.6
Gencode Gene: ENSG00000258366.9
Transcript (Including UTRs)
Position: hg38 chr20:63,658,291-63,695,980 Size: 37,690 Total Exon Count: 35 Strand: +
Coding Region
Position: hg38 chr20:63,659,403-63,695,785 Size: 36,383 Coding Exon Count: 34

Page Index

Sequence and Links

UniProtKB Comments

Protein Structure

Other Names

Methods

Data last updated at UCSC: 2021-06-20 19:51:40

Comments and Description Text from UniProtKB


	ID: RTEL1_HUMAN DESCRIPTION: RecName: Full=Regulator of telomere elongation helicase 1; EC=3.6.4.12; AltName: Full=Novel helicase-like; FUNCTION: ATP-dependent DNA helicase required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by promoting the disassembly of D loop recombination intermediates. Also required to regulate telomere length; probably due to its anti-recombinase function. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBCELLULAR LOCATION: Nucleus (By similarity). MISCELLANEOUS: Amplified in gastric tumors. SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SEQUENCE CAUTION: Sequence=CAI17958.1; Type=Erroneous gene model prediction; Sequence=CAM25345.1; Type=Erroneous gene model prediction;